1. New nervous reflex :
Discovered a nervous reflex to explain differential patency of two nostrils. Published in: J Appl. Physiology 1987:62:91-94; Year book of Pulmonary Diseases 1988-PP 34-35.This discovery was also included and appreciated in the year book of pulmonary medicine.
2. Evolved a new hypothesis :
Asthma and gastro esophageal reflux (GER) are closely linked but the mechanism was poorly understood. The mechanism was discovered and published in the leading international journal; J Asthma as the original article with commendable editorial remarks. This hypothesis was proved in the subsequent western studies. The hypothesis was an important discovery and therefore was discussed in the editorials of the top international journals with commendable remarks. Published in: J. Asthma 1983; 20:241-43; Annals of Allergy 1985; 55:344. In editorial of J. Asthma 1983;20:237-38 and Am Rev Respir Dis 1990;141:1391-92, Respiratory Medicine Book by Murray &NadelIInd Edition Vol.2 Pg.2424
3. Provided scientific proof that yogic breathing pranayama improves asthma :
“Yoga improves asthma” was believed but could not be proved in authentic scientific studies therefore at international level; yoga was never advised in treatment of asthma. Dr Singh carried out authentic studies including the first double blind placebo controlled study of the yoga. These studies showed that yoga improved asthma. Published in J. Asthma 1987;24:355-59; J. Asthma 1987;24:183-86; LANCET 1990;335:1381-83; Am Review Resp Disease 1990;141:A24. Also quoted in GINA guidelines for Asthma Management 2002 Pg. 114, Chest (India Edition) 2002; 3: 295.
4. New test to detect effect of pollution on healthy people :
It is difficult to detect effect of traffic pollution on the lungs of healthy people. Team of Dr Singh discovered that peak flow variability testing increases in people exposed to vehicular pollution. Published in: J Asthma 2003;4:81-86.
5. New mechanism in pathogenesis of asthma :
Allergens cause asthma by inducing inflammation in airway mucosa. However, still it is not known why airway inflammation persists despite of removal of allergens? Dr Singh discovered that friction at airway mucosa, generated during fast breathing such as coughing may be very high. High friction may cause injury to inflamed airway mucosa of asthmatic subjects. Repeated mucosal injury during coughing in asthmatic airways continues airway inflammation. Published in: Am Rev Respir Dis: 1993;147:A832; J Asthma 1999;36:419-426; JAPI 2000;48:501-504; JAPI 2000;48:343-45.